Chagas Disease remains underdiagnosed in Spain

A High Percentage of People from Latin America Infected with Chagas Disease, Study Finds

Newswise — A high percentage of people from Latin America are infected with the parasite that causes Chagas disease. This is the conclusion of an analysis of nearly 3,000 people from countries where the disease is endemic and who attended the International Health Service at Barcelona’s Hospital Clinic, over a 17-year period. The study, published in PLOS Neglected Tropical Diseases, was led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation.

Nearly 7 million people in the world are estimated to be infected with Trypanosoma cruzi, the parasite that causes Chagas disease. Although the vector that transmits the parasite (the kissing bug) is endemic in 21 Latin American countries, the parasite has spread globally due to migratory flows. In non-endemic countries, the parasite can be transmitted vertically, from mother to child or, less commonly, through blood or organ donations. In 30-40% of cases, the infection ends up damaging the heart and digestive system, causing Chagas disease.

Recommendations for Testing and Treatment

“It is therefore recommended that Latin Americans arriving in the country be tested in order to treat them if they are infected and, in the case of women of childbearing age, to prevent the vertical transmission of the parasite,” explains Irene Losada, coordinator of the Chagas Initiative and first co-author of the study, along with Pedro Laynez-Roldán, ISGlobal researcher and physician at the Clínic’s International Health Service.

Large Sample Study in a Non-Endemic Country

This retrospective study describes one of the largest samples of people at risk of infection in a non-endemic country: 2,820 Latin Americans, the vast majority from Bolivia, who attended the International Health Service of the Hospital Clinic of Barcelona between 2002 and 2019. Of the total number of people analysed, almost half (47%) were infected with T. cruzi and 17% had heart lesions typical of the disease. Although in most cases an electrocardiogram was sufficient to detect the lesions, an echocardiogram was needed in 10% of cases. “These results reinforce the importance of echocardiograms in the initial assessment of patients with T. cruzi infection,” says Laynez-Roldán.

Underdiagnosis Problem

The authors note that many people arriving from highly endemic regions of Latin America, such as Bolivia, had never been tested before. “The infection is clearly under-diagnosed even in Spain, one of the European countries with the highest diagnostic coverage,” warns Maria Jesús Pinazo, last author of the study, former researcher at ISGlobal and currently at DNDi.

The majority of the cases are women of working age, reflecting the migratory flows of recent years, which allows for better targeting of screening and prevention programmes.

Reference

Laynez-Roldán P, Losada-Galván I, Posada E et al. Characterization of Latin American migrants at risk for Trypanosoma cruzi infection in a non-endemic setting. Insights into initial evaluation of cardiac and digestive involvement. Plos NTD. 2023.

SDGs, Targets, and Indicators

1. Which SDGs are addressed or connected to the issues highlighted in the article?

• SDG 3: Good Health and Well-being
• SDG 10: Reduced Inequalities
• SDG 17: Partnerships for the Goals

2. What specific targets under those SDGs can be identified based on the article’s content?

• SDG 3.3: By 2030, end the epidemics of AIDS, tuberculosis, malaria, and neglected tropical diseases and combat hepatitis, water-borne diseases, and other communicable diseases.
• SDG 10.3: Ensure equal opportunity and reduce inequalities of outcome, including by eliminating discriminatory laws, policies, and practices and promoting appropriate legislation, policies, and action in this regard.
• SDG 17.16: Enhance the global partnership for sustainable development, complemented by multi-stakeholder partnerships that mobilize and share knowledge, expertise, technology, and financial resources.

3. Are there any indicators mentioned or implied in the article that can be used to measure progress towards the identified targets?

• Indicator for SDG 3.3: Percentage of people infected with Trypanosoma cruzi (the parasite that causes Chagas disease) in Latin American countries.
• Indicator for SDG 10.3: Percentage of Latin Americans arriving in non-endemic countries who are tested for Chagas disease.
• Indicator for SDG 17.16: Number of partnerships and collaborations between organizations and institutions to address Chagas disease and improve diagnosis and treatment.

Table: SDGs, Targets, and Indicators

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Source: newswise.com

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