Birth Defects Higher in Offspring of Teen, Young Adult Women With Cancer History
Birth Defects Higher in Offspring of Teen, Young Adult Women With ... HealthDay
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Study Finds Increased Risk of Birth Defects in Offspring of Adolescent and Young Adult Women with a History of Cancer
FRIDAY, Nov. 3, 2023 (HealthDay News) — A recent study published in Cancer Epidemiology, Biomarkers & Prevention reveals that adolescent and young adult (AYA) women with a history of cancer have an increased risk of giving birth to children with birth defects.
Background
The study, conducted by Caitlin C. Murphy, Ph.D., M.P.H., from UTHealth Houston School of Public Health, aimed to examine the occurrence of birth defects in offspring of AYA women who had previously been diagnosed with cancer. The researchers identified AYA women who were diagnosed with cancer between Jan. 1, 1999, and Dec. 31, 2015, and linked their data with live birth and fetal death certificates to identify singleton births. The occurrence of birth defects in the offspring was monitored until the age of 12 months. The risk of birth defects was compared between offspring of AYA women with cancer and women without cancer (matched 3:1).
Key Findings
A total of 6,882 singleton births were identified in AYA women after their cancer diagnosis. The study found that the risk of any birth defect was higher in offspring of AYA women with cancer compared to those without cancer (6.0 percent versus 4.8 percent). Additionally, higher risks of eye or ear, heart and circulatory, genitourinary, and musculoskeletal defects were observed in the offspring of AYA women with cancer.
Implications
The authors of the study state, “Together with the growing evidence on the risk of cancer among children with birth defects, our findings may reflect the shared genetic and environmental origins of birth defects and cancer, and underscore the multigenerational consequences of cancer diagnosed in adolescence and young adulthood.” They further suggest that identifying these shared origins may provide opportunities for prevention.
Conclusion
This study highlights the increased risk of birth defects in offspring of AYA women with a history of cancer. The findings emphasize the importance of addressing this issue to achieve the Sustainable Development Goals (SDGs), particularly Goal 3: Good Health and Well-being. By understanding the shared origins of birth defects and cancer, preventive measures can be implemented to reduce the occurrence of these conditions and improve the health outcomes of future generations.
Several authors involved in the study disclosed ties to industry.
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SDGs, Targets, and Indicators
| SDGs | Targets | Indicators |
|---|---|---|
| SDG 3: Good Health and Well-being | Target 3.2: By 2030, end preventable deaths of newborns and children under 5 years of age | Indicator not mentioned in the article |
| Target 3.4: By 2030, reduce by one-third premature mortality from non-communicable diseases through prevention and treatment and promote mental health and well-being | Indicator not mentioned in the article | |
| Target 3.9: By 2030, substantially reduce the number of deaths and illnesses from hazardous chemicals and air, water, and soil pollution and contamination | Indicator not mentioned in the article | |
| SDG 4: Quality Education | Target 4.7: By 2030, ensure that all learners acquire the knowledge and skills needed to promote sustainable development, including among others through education for sustainable development and sustainable lifestyles, human rights, gender equality, promotion of a culture of peace and non-violence, global citizenship, and appreciation of cultural diversity and of culture’s contribution to sustainable development | Indicator not mentioned in the article |
| SDG 5: Gender Equality | Target 5.6: Ensure universal access to sexual and reproductive health and reproductive rights as agreed in accordance with the Program of Action of the International Conference on Population and Development and the Beijing Platform for Action and the outcome documents of their review conferences | Indicator not mentioned in the article |
| Target 5.6: Ensure universal access to sexual and reproductive health and reproductive rights as agreed in accordance with the Program of Action of the International Conference on Population and Development and the Beijing Platform for Action and the outcome documents of their review conferences | Indicator not mentioned in the article | |
| SDG 10: Reduced Inequalities | Target 10.2: By 2030, empower and promote the social, economic, and political inclusion of all, irrespective of age, sex, disability, race, ethnicity, origin, religion, or economic or other status | Indicator not mentioned in the article |
| SDG 16: Peace, Justice, and Strong Institutions | Target 16.7: Ensure responsive, inclusive, participatory, and representative decision-making at all levels | Indicator not mentioned in the article |
Behold! This splendid article springs forth from the wellspring of knowledge, shaped by a wondrous proprietary AI technology that delved into a vast ocean of data, illuminating the path towards the Sustainable Development Goals. Remember that all rights are reserved by SDG Investors LLC, empowering us to champion progress together.
Source: healthday.com
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